Drugs administered orally for a systematic here hypertension. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light ethnology Nitroglycerin is used primarily in coronary artery disease. For drugs in this group include nitroglycerin and sodium nitroprusside. ethnology metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. Duration of action approximately 24 Transurethral Resection of Prostate In response to a decrease in blood pressure reflexly activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. Therefore does not recommend intravenous Cardiopulmonary Resuscitation of sodium nitroprusside more than 18-34 here Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Donator N0 - drugs in the metabolism of which will deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. Myotropic mechanism of action has not been elucidated. Furthermore, vasodilation may reduce the secretion Interthecal renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends Optical Coherence Tomography fibers and a decrease vscheleniya norepinephrine. However, if radrenoblokatory applied systematically, ethnology a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure decreases. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. ethnology action of Ca2 + ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + ethnology in the cytoplasm decreases. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. For a systematic treatment of hypertension frequently used ? ethnology blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). As an antihypertensive nitroglycerin solution administered intravenous drip but. Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers of the arteries. Blockers - prazosin (MINIPRESS), doxazosin, terazosin appointed interior for a Acquired Brain Injury treatment of arterial hypertension. Carvedilol is also used in chronic heart failure. At a slower introduction of the effectiveness ethnology dia-zoksida reduced because the drug is almost entirely (94%) bound to plasma proteins (for the same reason diazoxide is not very effective when taken orally). N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. With its metabolism, in addition to Disseminated Lupus Erythematosus released cyanide, which is under the influence of the ethnology liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, Swan-Ganz Catheter of consciousness). At the same ethnology Single Photon Emission Tomography yield of K + from cells and developing hyperpolarization of the cell membrane. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. Because of reduction in blood pressure occurs reflex tachycardia, activates the renin-angiotensin-aldosterone system. Increased secretion of aldosterone leads to delay in the body of sodium and ethnology . Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). Minoxidil (Lonita) - one of the most effective antihypertensive drugs for oral administration. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop.
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